anti-Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (AA 149-175)

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Antigen
Synonyms
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Dric ... show more
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice, A830040C14Rik, AC-3, Apopain, CPP32, Lice, Yama, mldy, CPP32B, SCA-1, xcpp32 show less
Alternatives
Epitope
AA 149-175, Asp175, cleaved
(39), (30), (30), (28), (27), (22), (18), (18), (14), (13), (13), (13), (13), (12), (10), (9), (9), (6), (6), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(490), (194), (143), (26), (17), (13), (13), (13), (12), (9), (6), (5), (5), (4), (3), (2), (1)
Host
Rabbit
(467), (79), (16), (3), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
This Caspase 3 antibody is un-conjugated
(26), (21), (17), (10), (9), (9), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(401), (209), (173), (110), (72), (56), (37), (30), (30), (23), (22), (10), (7), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 400 μL
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Immunogen This Cleaved antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 AA from human Cleaved.
Clone RB25833
Isotype Ig
Specificity This Cleaved-CASP3 (Asp175) antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 155~184 amino acids surrounding Asp175 of human CASP3.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP3 (CASP3 Antibody Abstract)
Background CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Synonyms: Caspase-3 subunit p12, Caspase-3 subunit p17, SREBP cleavage activity 1, SCA-1, Protein Yama, Cysteine protease CPP32, CPP-32, Apopain, Caspase-3, CASP-3,CPP32, CASP3
Molecular Weight 31608 DA
Gene ID 836
UniProt P42574
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes DB = 1:500, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (AA 149-175) (ABIN650861) Dot blot analysis of anti-Cleaved-CASP3 (Asp175) Antibody (ABIN650861) on nitrocellul...
Immunohistochemistry (IHC) image for anti-Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (AA 149-175) (ABIN650861) Cleaved-CASP3 (Asp175)Antibody (ABIN650861) IHC analysis in formalin fixed and paraff...
Product cited in: Luo, Sun, Wei et al.: "Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells." in: Biochemistry, Vol. 54, Issue 18, pp. 2895-902, 2015 (PubMed).

Background publications Mei, Yong, Liu et al.: "tRNA binds to cytochrome c and inhibits caspase activation." in: Molecular cell, Vol. 37, Issue 5, pp. 668-78, 2010 (PubMed).

Catalog No. ABIN650861
$324.50
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