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SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (pSer249)

Details for Product anti-SOX2 Antibody No. ABIN650873, Supplier: Log in to see
Antigen
  • Qscn6
  • Qsox
  • Sox-2
  • rSOx
  • ANOP3
  • MCOPS3
  • RGD1565646
  • SRY-box2
  • Xsox-2
  • anop3
  • mcops3
  • sox-2
  • lcc
  • ysb
  • cb236
  • wu:fb83g04
  • wu:fc14d07
  • zgc:65860
  • zgc:77389
Epitope
pSer249
43
23
21
14
14
13
10
7
7
6
5
5
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
313
88
44
13
9
7
7
5
5
4
4
3
2
1
1
1
Host
Rabbit
252
62
7
4
Clonality (Clone)
Polyclonal ()
Conjugate
This SOX2 antibody is un-conjugated
17
13
12
11
11
11
3
2
1
1
1
1
1
1
1
1
Application
Dot Blot (DB)
211
145
63
58
55
43
40
34
12
7
6
4
4
3
2
2
2
2
2
2
1
Supplier
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Immunogen This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S249 of human Sox2.
Clone RB27265
Isotype Ig
Specificity This phospho-Sox2-pS249 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 230-260 surrounding S249 of human Sox2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Sox2 (SOX2 Antibody Abstract)
Background This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Synonyms: SOX2,
Molecular Weight 34310 DA
Gene ID 6657
NCBI Accession NP_003097
UniProt P48431
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (pSer249) (ABIN650873) Dot blot analysis of anti-phospho-Sox2-pS249 Phospho-specific Pab(ABIN650873) on nitr...
Background publications Laga, Lai, Zhan et al.: "Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology." in: The American journal of pathology, Vol. 176, Issue 2, pp. 903-13, 2010 (PubMed).

Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).