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Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 713-742), (C-Term) antibody

Details for Product No. ABIN651060, Supplier: Login to see
Antigen
  • GR
  • gcr
  • grl
  • xGR
  • gccr
  • gr
  • zgc:113038
  • NR3C1
  • GCL
  • LOC100302444
  • Gcr
  • Grl
  • Grl-1
  • Grl1
  • GRL
  • GCCR
  • GCR
  • NO
  • GR-A
  • nr3c1
Alternatives
anti-Human Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) antibody for Western Blotting
Epitope
AA 713-742, C-Term
36
23
18
17
16
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14
14
13
11
10
7
5
5
5
5
4
3
3
3
3
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2
2
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2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
249
86
80
4
2
2
2
2
Host
Rabbit
203
59
6
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
21
16
9
7
6
6
3
3
3
3
3
3
3
3
3
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
191
107
78
45
44
33
32
20
18
8
3
2
2
2
1
Supplier
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Immunogen This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713-742 AA from the C-terminal region of human NR3C1.
Clone RB26107
Isotype Ig
Specificity This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 712-742 from the C-terminal region of human NR3C1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NR3C1 (NR3C1 Antibody Abstract)
Background NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.
Synonyms: Nuclear receptor subfamily 3 group C member 1, Glucocorticoid receptor, GR,GRL, NR3C1
Molecular Weight 81509 DA
Gene ID 2908
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways Nuclear Receptor Transcription Pathway
Application Notes WB = 1:1000, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 713-742), (C-Term) antibody (ABIN651060) Western blot analysis of NR3C1 Antibody (C-term) (ABIN651060) in A549 cell line lysat...
Immunohistochemistry (IHC) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 713-742), (C-Term) antibody (ABIN651060) NR3C1 Antibody (C-term) (ABIN651060) immunohistochemistry analysis in formalin fixed ...
Background publications Geelhoed, Steegers, Koper et al.: "Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study." in: BMC medical genetics, Vol. 11, pp. 39, 2010 (PubMed).

Wang, Frederick, Garabedian: "Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo." in: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26573-80, 2002 (PubMed).