Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 713-742), (C-Term) antibody

Details for Product No. ABIN651060, Supplier: Log in to see
Antigen
  • GR
  • gcr
  • grl
  • xGR
  • gccr
  • gr
  • zgc:113038
  • NR3C1
  • GCL
  • LOC100302444
  • Gcr
  • Grl
  • Grl-1
  • Grl1
  • GRL
  • GCCR
  • GCR
  • NO
  • GR-A
  • nr3c1
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • nuclear receptor subfamily 3, group C, member 1
  • glucocorticoid receptor
  • NR3C1
  • nr3c1
  • LOC100302444
  • Nr3c1
Alternatives
anti-Human Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) antibody for BioImaging
Epitope
AA 713-742, C-Term
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24
19
18
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14
11
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7
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5
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2
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1
1
1
1
1
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1
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1
Reactivity
Human
283
136
121
21
20
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10
6
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5
2
2
1
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1
Host
Rabbit
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83
6
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
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1
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1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
242
112
100
78
75
53
46
39
31
8
7
6
6
3
2
2
2
2
Options
Supplier
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Immunogen This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713-742 AA from the C-terminal region of human NR3C1.
Clone RB26107
Isotype Ig
Specificity This NR3C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 712-742 from the C-terminal region of human NR3C1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NR3C1 (NR3C1 Antibody Abstract)
Background NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.
Synonyms: Nuclear receptor subfamily 3 group C member 1, Glucocorticoid receptor, GR,GRL, NR3C1
Molecular Weight 81509 DA
Gene ID 2908
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Chromatin, Cell Structure
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process
Application Notes WB = 1:1000, IHC (p) = 1:50-100, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 713-742), (C-Term) antibody (ABIN651060) Western blot analysis of NR3C1 Antibody (C-term) (ABIN651060) in A549 cell line lysat...
Immunohistochemistry (IHC) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (AA 713-742), (C-Term) antibody (ABIN651060) NR3C1 Antibody (C-term) (ABIN651060) immunohistochemistry analysis in formalin fixed ...
Background publications Geelhoed, Steegers, Koper, van Rossum, Moll, Raat, Tiemeier, Hofman, Jaddoe: "Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study." in: BMC medical genetics, Vol. 11, pp. 39, 2010 (PubMed).

Wang, Frederick, Garabedian: "Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo." in: The Journal of biological chemistry, Vol. 277, Issue 29, pp. 26573-80, 2002 (PubMed).