Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN651232

Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5) (AA 261-289), (Center) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms GRP78, BIP, MIF2, grp78, hspa5a, BiP, GRP-78, HSPA5
Epitope
»Alternatives AA 261-289, Center
Reactivity
»Alternatives Human, Zebrafish (Danio rerio)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN651232
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen This HSPA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 AA from the Central region of human HSPA5.
Clone RB20813
Isotype Ig
Specificity This HSPA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the Central region of human HSPA5.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HSPA5
Background When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.
Synonyms: Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, Immunoglobulin heavy chain-binding protein, BiP, Heat shock 70 kDa protein 5, 78 kDa glucose-regulated protein, GRP-78,GRP78, HSPA5
Molecular Weight 72333 DA
Gene ID 3309
UniProt P11021
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Stem Cells, Protein Modifications, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Zhuang, Scolyer, Murali et al.: "Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 23, Issue 1, pp. 45-53, 2010 (PubMed).

Zhao, Zhang, Tian et al.: "Proteomic analysis of cell lines expressing small hepatitis B surface antigen revealed decreased glucose-regulated protein 78 kDa expression in association with higher susceptibility to apoptosis." in: Journal of medical virology, Vol. 82, Issue 1, pp. 14-22, 2009 (PubMed).

Alternatives for antigen "Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5)", type "Antibodies"
Hosts (91), (23), (6)
Reactivities (96), (69), (61), (12), (10), (8), (8), (7), (7), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Applications (106), (47), (32), (21), (18), (14), (10), (6), (3), (2), (1), (1), (1)
Conjugates (6), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Beacon