LINGO1 antibody (C-Term)

Catalog No. ABIN651289

Product Details anti-LINGO1 Antibody

Target: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Binding Specificity: AA 575-603, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LINGO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: C, Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LINGO-1(LRRN6A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LINGO-1(LRRN6A).

Clone: RB15362

Isotype: Ig Fraction

Application Details

Application Notes: IHC: 1:50. IHC: 1:125. WB: 1:1000-1:2000. IHC-P: 1:50~100. IHC: 1:250. IHC: 1:125

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-LINGO1 antibody (ABIN651289)

Towner, Jensen, Vaillant, Colman, Saunders, Giles, Wren: "Experimental validation of 5 in-silico predicted glioma biomarkers." in: Neuro-oncology, Vol. 15, Issue 12, pp. 1625-34, (2013) (PubMed).

Target Details for LINGO1

Target: LINGO1 (Leucine Rich Repeat and Ig Domain Containing 1 (LINGO1))

Alternative Name: LINGO-1 (LRRN6A) (LINGO1 Products)

Synonyms: lern1 antibody, lrrn6a antibody, unq201 antibody, DKFZp459P0736 antibody, LERN1 antibody, LRRN6A antibody, UNQ201 antibody, 4930471K13Rik antibody, AV148400 antibody, LINGO-1 antibody, Lrrn6a antibody, leucine rich repeat and Ig domain containing 1 antibody, LINGO1 antibody, lingo1 antibody, Lingo1 antibody

Background: LINGO-1 is functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. LINGO-1 is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.

Molecular Weight: 69101

Gene ID: 235402

NCBI Accession: NP_851419

UniProt: Q9D1T0