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HAS2 antibody (AA 138-166)

HAS2 Reactivity: Human, Mouse WB, FACS, IHC (p) Host: Rabbit Polyclonal RB22492 unconjugated
Catalog No. ABIN651874
  • Target See all HAS2 Antibodies
    HAS2 (Hyaluronan Synthase 2 (HAS2))
    Binding Specificity
    • 9
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 138-166
    Reactivity
    • 41
    • 23
    • 14
    Human, Mouse
    Host
    • 37
    • 13
    Rabbit
    Clonality
    • 37
    • 13
    Polyclonal
    Conjugate
    • 15
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HAS2 antibody is un-conjugated
    Application
    • 30
    • 21
    • 13
    • 11
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids of human HAS2.
    Clone
    RB22492
    Isotype
    IgG
    Top Product
    Discover our top product HAS2 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze-thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Expiry Date
    6 months
  • Lien, Lee, Jeng, Lin, Lu, Yao: "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance." in: Histopathology, Vol. 65, Issue 3, pp. 328-39, (2015) (PubMed).

    Kobayashi, Banno, Shimizu, Ueki, Tsuji, Masuda, Kisu, Nomura, Tominaga, Nagano, Saya, Aoki: "Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta." in: Placenta, Vol. 34, Issue 2, pp. 110-8, (2013) (PubMed).

  • Target
    HAS2 (Hyaluronan Synthase 2 (HAS2))
    Alternative Name
    HAS2 (HAS2 Products)
    Synonyms
    DG42 antibody, XHas2 antibody, Has2 antibody, hyaluronan synthase 2 antibody, hyaluronan synthase 2 S homeolog antibody, has2 antibody, HAS2 antibody, Has2 antibody, SHAS2 antibody, has2.S antibody
    Background
    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
    Molecular Weight
    63566
    Gene ID
    3037
    NCBI Accession
    NP_005319
    UniProt
    Q92819
    Pathways
    Glycosaminoglycan Metabolic Process
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