|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Caspase 1, Apoptosis-Related Cysteine Peptidase (Interleukin 1, Beta, Convertase) (CASP1) (N-Term) antibody
|Synonyms||ICE, P45, IL1BC, Il1bc, Ice, DCP-1, DCP1, l(2)01862, l(2)02132, DmelCG5370, CG5370, CASP1, LOC100033888|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
|2 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This CASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25~54 amino acids from the N-terminal region of human CASP1.|
|Description||Other names: Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, ICE, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, IL1BCE, IL1BC, CASP1|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25~54 amino acids from the N-terminal region of human CASP1.|
|Molecular Weight||45159 DA|
Background: CASP1 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This protein has been shown to induce cell apoptosis and may function in various developmental stages.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 50~100 Immunohistochemistry ~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Basak, Pathak, Bhattacharyya et al.: "NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4279-88, 2005 (PubMed).
Nasirudeen, Liu: "Gene expression profiling by microarray analysis reveals an important role for caspase-1 in dengue virus-induced p53-mediated apoptosis." in: Journal of medical virology, Vol. 81, Issue 6, pp. 1069-81, 2009 (PubMed).