|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Anaplastic Lymphoma Receptor tyrosine Kinase (ALK) (Center) antibody
|Synonyms||CD246, NBLST3, TFG/ALK, Tcrz, ALK|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644~673 amino acids from the center region of human ALK.|
|Description||Other names: Anaplastic lymphoma kinase, CD246 antigen|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644~673 amino acids from the center region of human ALK.|
|Molecular Weight||176417 DA|
Background: ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2,5)(p23,q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100 Immunohistochemistry ~~ 1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Neurology, Cell Structure|
|Restrictions||For Research Use only|
Morris, Kirstein, Valentine et al.: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).
Iwahara, Fujimoto, Wen et al.: "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system." in: Oncogene, Vol. 14, Issue 4, pp. 439-49, 1997 (PubMed).
Morris, Naeve, Mathew et al.: "ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)" in: Oncogene, Vol. 14, Issue 18, pp. 2175-88, 1997 (PubMed).