anti-AAK1 antibody (AA 186-216)

Details for Product anti-AAK1 Antibody No. ABIN652404
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AA 186-216, N-Term
(20), (20), (15), (13), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(90), (61), (42), (3), (1), (1), (1), (1), (1)
(87), (14), (6)
Clonality (Clone)
Polyclonal ()
This AAK1 antibody is un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(96), (52), (20), (10), (10), (7), (5), (4), (3), (2), (1)
Pubmed 2 references available
Quantity 400 μL
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Immunogen This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-216 AA from the N-terminal region of human AAK1.
Clone RB16487
Isotype Ig
Specificity This AAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194~223 amino acids from the n-terminal region of human AAK1.
Predicted Reactivity Cow (Bovine),Pig (Porcine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. AAK1 is a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.
Synonyms: AP2-associated protein kinase 1, Adaptor-associated kinase 1, AAK1, KIAA1048
Molecular Weight 93578 DA
Gene ID 22848
UniProt Q2M2I8
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AAK1 antibody (AA 186-216) (ABIN652404) Western blot analysis of AAK1 Antibody (N-term) (ABIN652404) in Ramos cell line lysat...
Background publications Henderson, Conner: "A novel AAK1 splice variant functions at multiple steps of the endocytic pathway." in: Molecular biology of the cell, Vol. 18, Issue 7, pp. 2698-706, 2007 (PubMed).

Takahashi, Furuchi, Naganuma: "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells." in: Cancer research, Vol. 66, Issue 24, pp. 11932-7, 2006 (PubMed).

Catalog No. ABIN652404
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