NEK3 (AA 331-361), (Center) antibody

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Antigen
Synonyms HSPK36, ATNEK3, NIMA-RELATED KINASE3, NIMA-related kinase 3, T8M17.60, T8M17_60
Epitope
AA 331-361, Center
(15), (15), (14), (13), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(47), (28), (13), (1), (1), (1)
Host
Rabbit
(55), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(51), (26), (15), (10), (6), (6), (6), (4), (1)
Pubmed 4 references available
Quantity 400 μL
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Immunogen This NEK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 AA from the Central region of human NEK3.
Clone RB2961
Isotype Ig
Specificity This NEK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339~368 amino acids from the center region of human NEK3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events. NEK3 is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation. However, the encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm.
Synonyms: Serine/threonine-protein kinase Nek3, NimA-related protein kinase 3, HSPK 36
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-NEK3 (AA 331-361), (Center) antibody NEK3 Antibody (K346) (ABIN652427) western blot analysis in CEM cell line lysates (35 ...
anti-NEK3 (AA 331-361), (Center) antibody (2) Western blot analysis of NEK3 (arrow) using rabbit polyclonal NEK3 Antibody (K346) (A...
Product cited in: McHale, Tomaszewski, Puthiyaveettil et al.: "Altered expression of prolactin receptor-associated signaling proteins in human breast carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 5, pp. 565-71, 2008 (PubMed).

Background publications Kimura, Okano: "Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3)." in: Cytogenetics and cell genetics, Vol. 95, Issue 3-4, pp. 177-82, 2002 (PubMed).

Schultz, Nigg: "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 4, Issue 10, pp. 821-30, 1994 (PubMed).

Schultz, Fry, Sütterlin et al.: "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 5, Issue 6, pp. 625-35, 1994 (PubMed).

Validation Images
Catalog No. ABIN652427
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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