SLC11A1 antibody (AA 250-276)

Catalog No. ABIN652453

Product Details anti-SLC11A1 Antibody

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Binding Specificity: AA 250-276

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC11A1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SLC11A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-276 amino acids from the Central region of human SLC11A1.

Clone: RB22005

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for SLC11A1

Target: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Alternative Name: SLC11A1 (SLC11A1 Products)

Synonyms: SLC11A1 antibody, NRAMP1 antibody, LSH antibody, NRAMP antibody, Bcg antibody, Itg antibody, Lsh antibody, Nramp1 antibody, Ity antibody, Nramp antibody, ity antibody, BCG antibody, solute carrier family 11 member 1 L homeolog antibody, solute carrier family 11 member 1 antibody, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 antibody, slc11a1.L antibody, SLC11A1 antibody, Slc11a1 antibody

Background: NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Molecular Weight: 59872

Gene ID: 6556

NCBI Accession: NP_000569

UniProt: P49279

Pathways: Transition Metal Ion Homeostasis, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus