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IL-1 beta antibody (AA 148-174)

IL1B Reactivity: Human, Mouse WB, FACS, IHC (p) Host: Rabbit Polyclonal RB21917 unconjugated
Catalog No. ABIN652470
  • Target See all IL-1 beta (IL1B) Antibodies
    IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
    Binding Specificity
    • 17
    • 15
    • 15
    • 15
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 148-174
    Reactivity
    • 122
    • 86
    • 43
    • 28
    • 24
    • 14
    • 8
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 174
    • 64
    • 6
    • 6
    • 4
    • 2
    • 1
    Rabbit
    Clonality
    • 180
    • 75
    • 1
    Polyclonal
    Conjugate
    • 135
    • 40
    • 23
    • 10
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IL-1 beta antibody is un-conjugated
    Application
    • 183
    • 107
    • 90
    • 46
    • 42
    • 39
    • 28
    • 17
    • 17
    • 15
    • 14
    • 14
    • 11
    • 10
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Pr, Rb
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This IL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-174 amino acids of human IL1B.
    Clone
    RB21917
    Isotype
    IgG
    Top Product
    Discover our top product IL1B Primary Antibody
  • Application Notes
    WB: 1:2000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Abdul-Muneer, Alikunju, Mishra, Schuetz, Szlachetka, Burnham, Haorah: "Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions." in: Brain, behavior, and immunity, Vol. 62, pp. 291-305, (2018) (PubMed).

    Liu, Wen, Chen, Wang, Huang, Tu: "Effects of Berberine on NLRP3 and IL-1β Expressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation." in: BioMed research international, Vol. 2016, pp. 2503703, (2016) (PubMed).

    Zhang, Liu, Huang, Su, Zhang, Wang, Li: "NF-?B activation and cell death after intracerebral hemorrhage in patients." in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, Vol. 35, Issue 7, pp. 1097-102, (2014) (PubMed).

    Liu, Tu, Chen, Wang, Hu, Dong: "Effects of Modified Simiao Decoction on IL-1 β and TNF α Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 406816, (2014) (PubMed).

  • Target
    IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
    Alternative Name
    IL1B (IL1B Products)
    Synonyms
    IL-1 antibody, IL1-BETA antibody, IL1F2 antibody, IL-1BETA antibody, IL1beta antibody, il1-b antibody, zgc:111873 antibody, IL-1B antibody, IL-1beta antibody, Il-1b antibody, IL1B antibody, IL-1 beta antibody, IL-1b antibody, interleukin 1 beta antibody, interleukin 1, beta antibody, IL1B antibody, il1b antibody, Il1b antibody
    Background
    IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (,CNS), is found to contribute to inflammatory pain hypersensitivity.
    Molecular Weight
    30748
    Gene ID
    3553
    NCBI Accession
    NP_000567
    UniProt
    P01584
    Pathways
    NF-kappaB Signaling, Interferon-gamma Pathway, TLR Signaling, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints, Inflammasome
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