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Interleukin 8 antibody (IL8) (AA 72-99)

Details for Product anti-IL8 Antibody No. ABIN652552, Supplier: Log in to see
Antigen
  • AMCF-I
  • CXCL8
  • cxcli2
  • EMF-1
  • GCP-1
  • GCP1
  • IL-8
  • IL8
  • il8
  • Il8
  • interleukin-8
  • K60
  • LECT
  • LUCT
  • lungkine
  • LYNAP
  • MDNCF
  • MONAP
  • NAF
  • NAP-1
  • NAP1
  • Scyb15
  • si:dkey-151b16.2
  • weche
Epitope
AA 72-99, C-Term
49
28
23
18
13
11
7
6
5
4
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
399
30
26
20
16
13
12
8
8
6
4
4
4
2
2
1
1
1
1
1
Host
Rabbit
289
216
9
7
7
4
2
Clonality (Clone)
Polyclonal ()
Conjugate
This Interleukin 8 antibody is un-conjugated
59
47
16
8
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
342
327
99
80
37
36
36
29
27
24
16
14
13
12
6
5
5
4
2
2
2
2
1
1
1
1
1
1
1
Supplier
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Immunogen This IL8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-99 AA from the C-terminal region of human IL8.
Clone RB20676
Isotype Ig
Specificity This IL8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70~99 amino acids from the C-terminal region of human IL8.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IL8 (IL8 Antibody Abstract)
Background IL8 is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor.
Synonyms: Interleukin-8, IL-8, C-X-C motif chemokine 8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil-activating peptide, MONAP, Emoctakin, MDNCF-a, IL8/NAP1 form I, GCP/IL-8 protein IV, Interleukin-8, IL-8(1-77), MDNCF-b, IL8/NAP1 form II, GCP/IL-8 protein II, (Ala-IL-8)77, IL-8(5-77), IL-8(6-77), Lymphocyte-derived neutrophil-activating factor, LYNAP, Neutrophil-activating factor, NAF, MDNCF-c, IL8/NAP1 form III, GCP/IL-8 protein I, (Ser-IL-8)72, IL-8(7-77), IL8/NAP1 form IV, GCP/IL-8 protein V, IL-8(8-77), IL8/NAP1 form V, GCP/IL-8 protein VI, IL-8(9-77), IL8/NAP1 form VI, GCP/IL-8 protein III , CXCL8, IL8
Pathways: Hepatitis C, Cytokine-cytokine receptor interaction, Pathways in cancer, Chemokine signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Malaria, Bladder cancer, Rheumatoid arthritis, Epithelial cell signaling in Helicobacter pylori infection, Chagas disease (American trypanosomiasis), Amoebiasis, Shigellosis
Molecular Weight 11098 Da
Gene ID 3576
UniProt P10145
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Interleukin 8 antibody (IL8) (AA 72-99) (ABIN652552) Western blot analysis of IL8 Antibody (C-term) (ABIN652552) in MDA-MB468 cell line ly...
Immunohistochemistry (IHC) image for anti-Interleukin 8 antibody (IL8) (AA 72-99) (ABIN652552) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with IL8 Antibody (...
Flow Cytometry (FACS) image for anti-Interleukin 8 antibody (IL8) (AA 72-99) (ABIN652552) IL8 Antibody (C-term) (ABIN652552) flow cytometric analysis of CEM cells (bottom hist...
Product cited in: Shao, Lu, Zhang, Wang, Li, Hu, Wang, Lin: "Interleukin-8 upregulates integrin ?3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K/Akt/NF-?B pathway." in: Cancer letters, Vol. 364, Issue 2, pp. 165-72, 2015

Bai, Tai, Li, Zhen, Gu, Jian, Wang, Lin, Zhao, Gong, Liang, Wang, Zhou: "Gankyrin activates IL-8 to promote hepatic metastasis of colorectal cancer." in: Cancer research, Vol. 73, Issue 14, pp. 4548-58, 2013

Background publications Baggiolini, Clark-Lewis: "Interleukin-8, a chemotactic and inflammatory cytokine." in: FEBS letters, Vol. 307, Issue 1, pp. 97-101, 1992

Holmes, Lee, Kuang, Rice, Wood: "Structure and functional expression of a human interleukin-8 receptor." in: Science (New York, N.Y.), Vol. 253, Issue 5025, pp. 1278-80, 1991