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Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody

Details for Product No. ABIN652752, Supplier: Log in to see
Antigen
  • SCNN1A
  • ENaCalpha
  • BESC2
  • ENaCa
  • SCNEA
  • SCNN1
  • alphaxENaC
  • besc2
  • enaca
  • scnn1
  • ENaC
  • Scnn1
  • mENaC
  • ENAC
Epitope
AA 365-391, Center
34
19
15
10
6
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
48
42
28
17
Host
Rabbit
83
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
69
46
35
22
18
5
2
2
1
1
Supplier
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Immunogen This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-391 AA from the Central region of human SCNN1A.
Clone RB21957
Isotype Ig
Specificity This SCNN1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371~400 amino acids from the Center region of human SCNN1A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SCNN1A (SCNN1A Antibody Abstract)
Background Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been sociated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids.
Synonyms: Alpha-NaCH, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, ENaCA, Amiloride-sensitive sodium channel subunit alpha, SCNN1A, SCNN1
Pathways: Aldosterone-regulated sodium reabsorption
Molecular Weight 28,328 Da Isoform 3 Da
Gene ID 6337
UniProt P37088
Research Area Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody (ABIN652752) Western blot analysis of SCNN1A Antibody (Center) (ABIN652752) in WiDr cell line lysa...
Immunohistochemistry (IHC) image for anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody (ABIN652752) Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SCNN1A Antibod...
Immunofluorescence (IF) image for anti-Sodium Channel, Nonvoltage-Gated 1 alpha (SCNN1A) (AA 365-391), (Center) antibody (ABIN652752) Confocal immunofluorescent analysis of SCNN1A Antibody (Center) (ABIN652752) with Hel...
Background publications Azad, Rauh, Vermeulen et al.: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, 2009 (PubMed).