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Glutaminase antibody (C-Term)

GLS Reactivity: Human, Mouse, Rat WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB22875 unconjugated
Catalog No. ABIN652757
  • Target See all Glutaminase (GLS) Antibodies
    Glutaminase (GLS)
    Binding Specificity
    • 15
    • 13
    • 12
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 516-545, C-Term
    Reactivity
    • 62
    • 41
    • 30
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 61
    • 7
    Rabbit
    Clonality
    • 51
    • 17
    Polyclonal
    Conjugate
    • 30
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Glutaminase antibody is un-conjugated
    Application
    • 54
    • 27
    • 21
    • 17
    • 8
    • 8
    • 7
    • 6
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This GLS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human GLS.
    Clone
    RB22875
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000. IF: 1:25. IF: 1:25. IF: 1:25. WB: 1:1000. WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid freeze-thaw cycles.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
    Expiry Date
    6 months
  • Lukey, Greene, Erickson, Wilson, Cerione: "The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy." in: Nature communications, Vol. 7, pp. 11321, (2016) (PubMed).

  • Target
    Glutaminase (GLS)
    Alternative Name
    GLS (GLS Products)
    Synonyms
    Glut antibody, RATGLUT antibody, gls antibody, si:dz87i4.2 antibody, wu:fa97e05 antibody, GA antibody, PAG antibody, AAD20 antibody, GAC antibody, GAM antibody, GLS1 antibody, KGA antibody, AI314027 antibody, 6330442B14 antibody, B230365M23Rik antibody, CG8772 antibody, CG8872 antibody, Dmel\\CG42708 antibody, Dmel_CG8772 antibody, BA3155 antibody, glutaminase antibody, glutaminase b antibody, Glutaminase antibody, glutaminase kidney isoform, mitochondrial antibody, Gls antibody, GLS antibody, gls antibody, glsb antibody, glsA2 antibody, glsA-2 antibody, Arnit_3113 antibody, Celal_2913 antibody, Celly_0289 antibody, Weevi_2101 antibody, Mesop_4683 antibody, LOC100069617 antibody
    Background
    Sahai (1983) demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a neurotransmitter(Prusiner, 1981). High heritability of platelet glutaminase was indicated by studies of Sahai and Vogel (1983) [PubMed 6682827] who found an intraclass correlation coefficient of 0.96 for monozygotic twins and 0.53 for dizygotic twins.
    Molecular Weight
    73461
    Gene ID
    2744
    NCBI Accession
    NP_001243239, NP_055720
    UniProt
    O94925
    Pathways
    Feeding Behaviour, Dicarboxylic Acid Transport, Warburg Effect
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