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Unc-13 Homolog B (C. Elegans) (UNC13B) (AA 1062-1091), (Center) antibody

Details for Product No. ABIN652852, Supplier: Log in to see
Antigen
  • UNC13B
  • MUNC13
  • UNC13
  • Unc13h2
  • Munc13-1
  • Munc13-2
  • Unc13a
  • Unc13h1
Epitope
AA 1062-1091, Center
34
18
17
15
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
63
44
20
2
Host
Rabbit
74
11
5
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
8
8
8
7
7
7
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
69
57
11
9
5
5
2
2
2
2
1
Supplier
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Immunogen This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 AA from the Central region of human UNC13B.
Clone RB22476
Isotype Ig
Specificity This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1069~1099 amino acids from the Center region of human UNC13B.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name UNC13B (UNC13B Antibody Abstract)
Background UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
Synonyms: Munc13-2, munc13, Protein unc-13 homolog B, UNC13B, UNC13
Molecular Weight 180679 DA
Gene ID 10497
UniProt O14795
Research Area Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Unc-13 Homolog B (C. Elegans) (UNC13B) (AA 1062-1091), (Center) antibody (ABIN652852) Western blot analysis of UNC13B Antibody (Center) (ABIN652852) in 293 cell line lysat...
Flow Cytometry (FACS) image for anti-Unc-13 Homolog B (C. Elegans) (UNC13B) (AA 1062-1091), (Center) antibody (ABIN652852) UNC13B Antibody (Center) (ABIN652852) flow cytometric analysis of 293 cells (right hi...
Product cited in: Kasmapour, Gronow, Bleck et al.: "Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 50, pp. 20485-90, 2012 (PubMed).

Background publications Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).