Chromobox Homolog 1 (CBX1) (C-Term), (AA 128-155) antibody

Details for Product No. ABIN652861
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Antigen
Synonyms Cbx, Cbx-rs2, E430007M08Rik, HP1B, Hp1beta, M31, MOD1, CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, p25beta, cbx1, wu:fe14b09, zgc:55739
Epitope
C-Term, AA 128-155
(11), (7), (5), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(63), (30), (23), (14), (13), (8), (7), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(36), (16), (13), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(59), (29), (12), (12), (10), (9), (8), (5), (4), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN652861
291.50 $
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Immunogen This CBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 AA from the C-terminal region of human CBX1.
Clone RB23535
Isotype Ig
Specificity This CBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135~164 amino acids from the C-terminal region of human CBX1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CBX1
Background CBX1 is a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression.
Synonyms: p25beta, HP1Hsbeta, Heterochromatin protein p25, M31, Modifier 1 protein, Heterochromatin protein 1 homolog beta, HP1 beta, Chromobox protein homolog 1, CBX1, CBX
Molecular Weight 21418 DA
Gene ID 10951
UniProt P83916
Research Area Neurology
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Chromobox Homolog 1 (CBX1) (C-Term), (AA 128-155) antibody Western blot analysis of CBX1 Antibody (C-term) (ABIN652861) in MCF-7, A2058, Y79 cell line lysates (35 µg/lane). CBX1 (arrow) was detected using the purified polyclonal antibody.
anti-Chromobox Homolog 1 (CBX1) (C-Term), (AA 128-155) antibody (2) CBX1 Antibody (C-term) (ABIN652861) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-Chromobox Homolog 1 (CBX1) (C-Term), (AA 128-155) antibody (3) CBX1 Antibody (C-term) (ABIN652861) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Aagaard, Laible, Selenko et al.: "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31." in: The EMBO journal, Vol. 18, Issue 7, pp. 1923-38, 1999 (PubMed).

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