SLC8A1 antibody (AA 296-325)

Catalog No. ABIN652886

Product Details anti-SLC8A1 Antibody

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Binding Specificity: AA 296-325

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC8A1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SLC8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human SLC8A1.

Clone: RB21687

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for SLC8A1

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Alternative Name: SLC8A1 (SLC8A1 Products)

Synonyms: NCX1 antibody, AI852629 antibody, AV344025 antibody, D930008O12Rik antibody, Ncx1 antibody, Ncx antibody, SLC8A1 antibody, ncx1n antibody, solute carrier family 8 member A1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1 antibody, solute carrier family 8 (sodium/calcium exchanger), member 1b antibody, sodium/calcium exchanger 1 antibody, SLC8A1 antibody, Slc8a1 antibody, slc8a1b antibody, Tsp_07038 antibody

Background: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) centration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

Molecular Weight: 108547

Gene ID: 6546

NCBI Accession: NP_001106271, NP_001106272, NP_001106273, NP_001239553, NP_066920

UniProt: P32418

Pathways: Myometrial Relaxation and Contraction