TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins.
Synonyms: Lymphocyte-associated receptor of death, LARD, Apo-3, Apoptosis-inducing receptor AIR, Protein WSL, Protein WSL-1, Death receptor 3, Apoptosis-mediating receptor TRAMP, Apoptosis-mediating receptor DR3, Tumor necrosis factor receptor superfamily member 25, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779