NAMPT antibody (AA 400-426)

Catalog No. ABIN652958

Product Details anti-NAMPT Antibody

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Binding Specificity: AA 400-426

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAMPT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NAMPT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-426 amino acids from the Central region of human NAMPT.

Clone: RB22920

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-NAMPT antibody (ABIN652958)

Zhang, Tong, Huang: "Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells." in: PLoS ONE, Vol. 8, Issue 7, pp. e69963, (2013) (PubMed).

Pittelli, Formentini, Faraco, Lapucci, Rapizzi, Cialdai, Romano, Moneti, Moroni, Chiarugi: "Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 34106-14, (2010) (PubMed).

Target Details for NAMPT

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Alternative Name: NAMPT (NAMPT Products)

Synonyms: 1110035O14Rik antibody, PBEF antibody, PBEF1 antibody, VF antibody, VISFATIN antibody, AI314458 antibody, AI480535 antibody, NAmPRTase antibody, Pbef antibody, Pbef1 antibody, Visfatin antibody, visfatin antibody, pbef antibody, pbef1 antibody, nicotinamide phosphoribosyltransferase antibody, Nicotinamide phosphoribosyltransferase antibody, nicotinamide phosphoribosyltransferase S homeolog antibody, NAMPT antibody, Nampt antibody, nampt antibody, Smon_0680 antibody, Mrub_2845 antibody, Cseg_3704 antibody, BC1002_3997 antibody, Ftrac_2686 antibody, Varpa_5681 antibody, Celal_3900 antibody, Deima_0880 antibody, BC1001_3724 antibody, Celly_1696 antibody, Clole_1542 antibody, Tsp_05934 antibody, nampt.S antibody

Background: NAMPT catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Molecular Weight: 55521

Gene ID: 10135

NCBI Accession: NP_005737

UniProt: P43490