KCNJ11 antibody (N-Term)

Catalog No. ABIN653157

Product Details anti-KCNJ11 Antibody

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ11 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Predicted Reactivity: Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCNJ11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNJ11.

Clone: RB21238

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for KCNJ11

Target: KCNJ11 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11))

Alternative Name: KCNJ11 (KCNJ11 Products)

Synonyms: kir6.2 antibody, Kir6.2 antibody, mBIR antibody, BIR antibody, HHF2 antibody, IKATP antibody, KIR6.2 antibody, PHHI antibody, TNDM3 antibody, potassium voltage-gated channel subfamily J member 11 antibody, potassium inwardly-rectifying channel, subfamily J, member 11 antibody, potassium inwardly rectifying channel, subfamily J, member 11 antibody, KCNJ11 antibody, kcnj11 antibody, Kcnj11 antibody

Background: ATP-sensitive potassium (K(ATP)) channels are found in endocrine cells, neurons and both smooth and striated muscle, where they play an important role in controlling insulin secretion and vascular tone, and protect neurons under metabolic stress. Kir6.2 is a member of the inward rectifier potassium channel family, which is characterised by a greater tendency to allow potassium flow into the cell rather than out of it. It associates with the sulphonylurea receptor SUR1/ABCC8 to form a subfamily of K(ATP) channels that, when mutated or misregulated, are associated with forms of hyperinsulinemic hypoglycemia, neonatal diabetes, or pre-disposition to type 2 diabetes mellitus.

Molecular Weight: 43541

Gene ID: 3767

NCBI Accession: NP_001159762

UniProt: Q14654

Pathways: Negative Regulation of Hormone Secretion