|+1 404 474 4654|
|+1 888 205 9894 (TF)|
TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (Center) antibody
|Synonyms||TAB1, 3'-Tab1, MGC57664|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This TAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227~256 amino acids from the Center region of human TAB1.|
|Description||Other names: TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB1, MAP3K7IP1|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This TAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227~256 amino acids from the Center region of human TAB1.|
|Molecular Weight||54644 DA|
Background: TAB1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
Neil, Schiemann: "Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression." in: Cancer research, Vol. 68, Issue 5, pp. 1462-70, 2008 (PubMed).
Prickett, Ninomiya-Tsuji, Broglie et al.: "TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19245-54, 2008 (PubMed).
Isono, Kim, Ando et al.: "Suppression of cell invasiveness by periostin via TAB1/TAK1." in: International journal of oncology, Vol. 35, Issue 2, pp. 425-32, 2009 (PubMed).