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Adenylate Cyclase 7 (Adcy7) (AA 510-539), (Center) antibody

Details for Product No. ABIN653337
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Antigen
Synonyms ADCY7, ADCY4a, ac7, AC7, AA407758
Epitope
AA 510-539, Center
(8), (6), (1), (1), (1), (1), (1)
Reactivity
Human
(30), (17), (13), (12), (12)
Host
Rabbit
(32), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(18), (16), (14), (11), (10), (6), (3), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN653337
291.50 $
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Immunogen This ADCY7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 510-539 AA from the Central region of human ADCY7.
Clone RB22830
Isotype Ig
Specificity This ADCY7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 517~547 amino acids from the Center region of human ADCY7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADCY7
Background ADCY7 encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.
Synonyms: Adenylyl cyclase 7, ATP pyrophosphate-lyase 7, Adenylate cyclase type VII, Adenylate cyclase type 7, KIAA0037, ADCY7
Molecular Weight 120308 DA
Gene ID 113
UniProt P51828
Research Area Cancer, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Adenylate Cyclase 7 (Adcy7) (AA 510-539), (Center) antibody Western blot analysis of ADCY7 Antibody (Center) (ABIN653337) in MCF-7 cell line lysates (35 µg/lane). ADCY7 (arrow) was detected using the purified polyclonal antibody.
anti-Adenylate Cyclase 7 (Adcy7) (AA 510-539), (Center) antibody (2) Formalin-fixed and paraffin-embedded human breast carcinoma reacted with ADCY7 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Adenylate Cyclase 7 (Adcy7) (AA 510-539), (Center) antibody (3) ADCY7 Antibody (Center) (ABIN653337) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Hines, Hoffman, Bhave et al.: "A sex-specific role of type VII adenylyl cyclase in depression." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 48, pp. 12609-19, 2006 (PubMed).

Jiang, Collins, Davis et al.: "Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII." in: The Journal of biological chemistry, Vol. 283, Issue 34, pp. 23429-39, 2008 (PubMed).

Townsend, Holliday, Fenyk et al.: "Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide." in: The Journal of biological chemistry, Vol. 284, Issue 2, pp. 784-91, 2009 (PubMed).

Validation Images
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