Fanconi Anemia, Complementation Group C (FANCC) (C-Term), (AA 527-555) antibody

Details for Product No. ABIN653475
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Antigen
Synonyms zgc:154105, FANCC, fa3, fac, facc, FA3, FAC, FACC, BB116513, Facc
Epitope
C-Term, AA 527-555
(24), (8), (7), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(74), (16), (13), (12), (2), (2), (1)
Host
Rabbit
(62), (15)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
(66), (21), (20), (19), (16), (10), (9), (9), (9), (4), (4), (3), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN653475
238.50 $
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Immunogen This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 AA from the C-terminal region of human FANCC.
Clone RB24076
Isotype Ig
Specificity This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529~558 amino acids from the C-terminal region of human FANCC.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FANCC
Background The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This protein is for complementation group C.
Synonyms: Fanconi anemia group C protein, Protein FACC ,FACC, FAC, FANCC
Molecular Weight 63429 Da
Gene ID 2176
UniProt Q00597
Research Area Neurology
Application Notes WB = 1:1000, IF = 1:25, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Fanconi Anemia, Complementation Group C (FANCC) (C-Term), (AA 527-555) antibody FANCC Antibody (C-term) (ABIN653475) western blot analysis in HL-60,HepG2 cell line lysates (35 µg/lane).This demonstrates the FANCC antibody detected the FANCC protein (arrow).
anti-Fanconi Anemia, Complementation Group C (FANCC) (C-Term), (AA 527-555) antibody (2) FANCC Antibody (C-term)(ABIN653475) IHC analysis in formalin fixed and paraffin embedded testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-Fanconi Anemia, Complementation Group C (FANCC) (C-Term), (AA 527-555) antibody (3) FANCC Antibody (C-term) (ABIN653475) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Sinha, Singh, Alam et al.: "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma." in: Molecular cancer, Vol. 7, pp. 84, 2009 (PubMed).

Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).

Michiels, Laplanche, Boulet et al.: "Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk." in: Carcinogenesis, Vol. 30, Issue 5, pp. 763-8, 2009 (PubMed).

McWilliams, Bamlet, de Andrade et al.: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, 2009 (PubMed).

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