PDHA1 antibody (AA 226-255)

Catalog No. ABIN653604

Product Details anti-PDHA1 Antibody

Target: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Binding Specificity: AA 226-255

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDHA1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Zf, B, Pr, M, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDHA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-255 amino acids from the Central region of human PDHA1.

Clone: RB24303

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PDHA1

Target: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Alternative Name: PDHA1 (PDHA1 Products)

Synonyms: PDHA antibody, PDHCE1A antibody, PHE1A antibody, Pdha-1 antibody, pdha antibody, phe1a antibody, pdhce1a antibody, im:6895726 antibody, pdha1 antibody, wu:fd18b01 antibody, wu:fo96f03 antibody, zgc:73271 antibody, zgc:86692 antibody, Pdha1 antibody, wu:fp73b04 antibody, zgc:92705 antibody, NI36_05250 antibody, pdha1-a antibody, pdha1-b antibody, pyruvate dehydrogenase E1 alpha 1 subunit antibody, pyruvate dehydrogenase E1 alpha 1 antibody, pyruvate dehydrogenase (lipoamide) alpha 1 antibody, pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene antibody, 2-oxo acid dehydrogenase antibody, pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha antibody, pyruvate dehydrogenase alpha subunit protein antibody, pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit antibody, precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit antibody, pyruvate dehydrogenase antibody, pyruvate dehydrogenase E1 alpha 1 subunit a antibody, pyruvate dehydrogenase E1 alpha 1 subunit b antibody, pyruvate dehydrogenase E1 component subunit alpha antibody, pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog antibody, PDHA1 antibody, Pdha1 antibody, pdha1 antibody, LOC719277 antibody, VNG_RS07485 antibody, RR_RS04695 antibody, pdhA1 antibody, pdha1a antibody, pdha1b antibody, NI36_RS05240 antibody, pdha1.S antibody

Background: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome.

Molecular Weight: 43296

Gene ID: 5160

NCBI Accession: NP_000275, NP_001166925, NP_001166926, NP_001166927

UniProt: P08559

Pathways: Warburg Effect