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Tubulin Folding Cofactor E (TBCE) (AA 364-392), (Center) antibody

Details for Product No. ABIN653623, Supplier: Log in to see
Antigen
  • HRD
  • KCS
  • KCS1
  • pac2
  • 2610206D02Rik
  • C530005D02Rik
  • pmn
Epitope
AA 364-392, Center
15
10
7
6
3
2
1
1
Reactivity
Human
45
18
16
Host
Rabbit
44
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
33
18
11
5
3
2
1
Supplier
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Immunogen This TBCE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 AA from the Central region of human TBCE.
Clone RB24405
Isotype Ig
Specificity This TBCE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371~400 amino acids from the Central region of human TBCE.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TBCE (TBCE Antibody Abstract)
Background Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex, interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Synonyms: Tubulin-folding cofactor E, Tubulin-specific chaperone E, TBCE
Molecular Weight 59346 DA
Gene ID 6905
NCBI Accession NP_003184
Research Area Signaling, Protein Modifications, Neurology
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Tubulin Folding Cofactor E (TBCE) (AA 364-392), (Center) antibody (ABIN653623) TBCE Antibody (Center) (ABIN653623) western blot analysis in CEM,K562 cell line lysat...
Background publications Biernacki, Marina, Zhang et al.: "Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells." in: Cancer research, Vol. 70, Issue 3, pp. 906-15, 2010 (PubMed).

Lindgren, Heid, Randall et al.: "Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution." in: PLoS genetics, Vol. 5, Issue 6, pp. e1000508, 2009 (PubMed).

Padidela, Kelberman, Press et al.: "Mutation in the TBCE gene is associated with hypoparathyroidism-retardation-dysmorphism syndrome featuring pituitary hormone deficiencies and hypoplasia of the anterior pituitary and the corpus callosum." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 8, pp. 2686-91, 2009 (PubMed).

Jin, Pan, Liu et al.: "Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation." in: Development (Cambridge, England), Vol. 136, Issue 9, pp. 1571-81, 2009 (PubMed).

Parvari, Hershkovitz, Kanis et al.: "Homozygosity and linkage-disequilibrium mapping of the syndrome of congenital hypoparathyroidism, growth and mental retardation, and dysmorphism to a 1-cM interval on chromosome 1q42-43." in: American journal of human genetics, Vol. 63, Issue 1, pp. 163-9, 1998 (PubMed).