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TBCE antibody (Tubulin Folding Cofactor E) (AA 364-392)

Details for Product anti-TBCE Antibody No. ABIN653623, Supplier: Log in to see
Antigen
  • 2610206D02Rik
  • C530005D02Rik
  • HRD
  • KCS
  • KCS1
  • pac2
  • pmn
Epitope
AA 364-392, Center
15
10
7
6
3
2
1
1
Reactivity
Human
52
20
18
Host
Rabbit
50
3
Clonality (Clone)
Polyclonal ()
Conjugate
This TBCE antibody is un-conjugated
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
37
18
12
11
7
2
2
2
1
Supplier
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Immunogen This TBCE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 AA from the Central region of human TBCE.
Clone RB24405
Isotype Ig
Specificity This TBCE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371~400 amino acids from the Central region of human TBCE.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TBCE (TBCE Antibody Abstract)
Background Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex, interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Synonyms: Tubulin-folding cofactor E, Tubulin-specific chaperone E, TBCE
Molecular Weight 59346 DA
Gene ID 6905
NCBI Accession NP_003184
Research Area Signaling, Protein Modifications, Neurology
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TBCE antibody (Tubulin Folding Cofactor E) (AA 364-392) (ABIN653623) TBCE Antibody (Center) (ABIN653623) western blot analysis in CEM,K562 cell line lysat...
Background publications Biernacki, Marina, Zhang, Liu, Bruns, Cai, Neuberg, Canning, Alyea, Soiffer, Brusic, Ritz, Wu: "Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells." in: Cancer research, Vol. 70, Issue 3, pp. 906-15, 2010 (PubMed).

Padidela, Kelberman, Press, Al-Khawari, Hindmarsh, Dattani: "Mutation in the TBCE gene is associated with hypoparathyroidism-retardation-dysmorphism syndrome featuring pituitary hormone deficiencies and hypoplasia of the anterior pituitary and the corpus callosum." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 8, pp. 2686-91, 2009 (PubMed).

Lindgren, Heid, Randall, Lamina, Steinthorsdottir, Qi, Speliotes, Thorleifsson, Willer, Herrera, Jackson, Lim, Scheet, Soranzo, Amin, Aulchenko, Chambers, Drong, Luan, Lyon, Rivadeneira, Sanna, Timpson, Zillikens, Zhao, Almgren, Bandinelli, Bennett, Bergm: "Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution." in: PLoS genetics, Vol. 5, Issue 6, pp. e1000508, 2009 (PubMed).

Jin, Pan, Liu, Wang, Xu, Zhang: "Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation." in: Development (Cambridge, England), Vol. 136, Issue 9, pp. 1571-81, 2009 (PubMed).

Parvari, Hershkovitz, Kanis, Gorodischer, Shalitin, Sheffield, Carmi: "Homozygosity and linkage-disequilibrium mapping of the syndrome of congenital hypoparathyroidism, growth and mental retardation, and dysmorphism to a 1-cM interval on chromosome 1q42-43." in: American journal of human genetics, Vol. 63, Issue 1, pp. 163-9, 1998 (PubMed).