|+1 404 474 4654|
|+1 888 205 9894 (TF)|
NAL11 (Center) antibody
Western Blotting (WB), Immunohistochemistry (IHC)
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This NAL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467~497 amino acids from the Central region of human NAL11.|
|Description||Other names: PAAD-and NACHT domain-containing protein 10, Nucleotide-binding oligomerization domain protein 17, PYRIN-containing APAF1-like protein 6, NACHT, LRR and PYD domains-containing protein 11,PYPAF6, PAN10, NOD17, NALP11, NLRP11|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This NAL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467~497 amino acids from the Central region of human NAL11.|
|Molecular Weight||117779 DA|
Background: NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100 Flow cytometric~~1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Chromatin, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Dowds, Masumoto, Chen et al.: "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product." in: Biochemical and biophysical research communications, Vol. 302, Issue 3, pp. 575-80, 2003 (PubMed).
Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).
Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).