NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Synonyms: PAAD-and NACHT domain-containing protein 10, Nucleotide-binding oligomerization domain protein 17, PYRIN-containing APAF1-like protein 6, NACHT, LRR and PYD domains-containing protein 11,PYPAF6, PAN10, NOD17, NALP11, NLRP11