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NAL11 (Center) antibody

Details for Product No. ABIN653949
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Antigen
Epitope
Center
(1)
Reactivity
Human
(1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN653949
291.50 $
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Immunogen This NAL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467~497 amino acids from the Central region of human NAL11.
Specificity This NAL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467~497 amino acids from the Central region of human NAL11.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
Synonyms: PAAD-and NACHT domain-containing protein 10, Nucleotide-binding oligomerization domain protein 17, PYRIN-containing APAF1-like protein 6, NACHT, LRR and PYD domains-containing protein 11,PYPAF6, PAN10, NOD17, NALP11, NLRP11
Molecular Weight 117779 DA
Gene ID 204801
UniProt P59045
Research Area Chromatin, Signaling, Cell Structure
Application Notes Western blotting= 1:100-500, Immunohistochemistry = 1:50-100 ,Flow cytometric=1:10-50
Comment

Background: NAL11 are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NAL11 are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.

Restrictions For Research Use only
Concentration 0.25 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-NAL11 (Center) antibody Western blot analysis of NAL11 Antibody (Center) (ABIN653949) in HL-60 cell line lysates (35 µg/lane). NAL11 (arrow) was detected using the purified polyclonal antibody.
anti-NAL11 (Center) antibody (2) NAL11 Antibody (Center) (ABIN653949) IHC analysis in formalin fixed and paraffin embedded tonsil followed by peroxidase conjugation of the secondary antibody and DAB staining
anti-NAL11 (Center) antibody (3) NAL11 Antibody (Center) (ABIN653949) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Dowds, Masumoto, Chen et al.: "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product." in: Biochemical and biophysical research communications, Vol. 302, Issue 3, pp. 575-80, 2003 (PubMed).

Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis...." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).

Validation Images
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