ADAM Metallopeptidase with thrombospondin Type 1 Motif, 17 (ADAMTS7) (N-Term) antibody

Antigen: ADAM Metallopeptidase with thrombospondin Type 1 Motif, 17 (ADAMTS7)

Synonyms: TTP, VWFCP, C9orf8, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, PRO4389, MGC126403, FLJ16363, FLJ32769, AI605170, ADAMTS-12, Gm710, ADAMTS17, ADAMTS12, ADAMTS13, ADAM-TS7, DKFZp434H204

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654063

Additional Information

Alternative name: ADAMTS17

Gene ID: 170691

UniProt: Q8TE56, NP_620688.2

Immunogen: This ADAMTS17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-191 amino acids from the N-terminal region of human ADAMTS17.

Isotype: Ig

Description: Other names: A disintegrin and metalloproteinase with thrombospondin motifs 17,ADAMTS17,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ADAMTS17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-191 amino acids from the N-terminal region of human ADAMTS17.

Molecular Weight: 121127 DA

Comments:

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Publications

Product: Gudbjartsson, Walters, Thorleifsson et al.: "Many sequence variants affecting diversity of adult human height." in: Nature genetics, Vol. 40, Issue 5, pp. 609-15, 2008 (PubMed).

Sovio, Bennett, Millwood et al.: "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966." in: PLoS genetics, Vol. 5, Issue 3, pp. e1000409, 2009 (PubMed).

Morales, Al-Sharif, Khalil et al.: "Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature." in: American journal of human genetics, Vol. 85, Issue 5, pp. 558-68, 2009 (PubMed).

Ichikawa, Koller, Padgett et al.: "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 25, Issue 8, pp. 1821-9, 2010 (PubMed).