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gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-890), (C-Term) antibody

Details for Product No. ABIN654172, Supplier: Login to see
Antigen
  • Gpr51
  • GABABR2
  • GPR51
  • GPRC3B
  • HG20
  • HRIHFB2099
  • Gb2
  • Gm425
  • GABA(B)R2
  • si:dkey-190l1.2
Epitope
AA 861-890, C-Term
35
25
24
16
14
13
6
5
4
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
131
121
90
8
8
5
5
5
4
3
2
1
1
1
1
1
Host
Rabbit
125
46
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
10
8
7
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
130
73
42
40
40
35
18
6
4
1
1
Supplier
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Immunogen This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 AA from the C-terminal region of human GABBR2.
Clone RB24610
Isotype Ig
Specificity This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 868-898 amino acids from the C-terminal region of human GABBR2.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GABBR2 (GABBR2 Antibody Abstract)
Background The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Synonyms: Gamma-aminobutyric acid type B receptor subunit 2,GABBR2,GPR51, GPRC3B
Molecular Weight 105821 DA
Gene ID 9568
NCBI Accession NP_005449
UniProt O75899
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) (AA 861-890), (C-Term) antibody (ABIN654172) GABBR2 antibody (C-term) (ABIN654172) immunohistochemistry analysis in formalin fixed...
Background publications Oblak, Gibbs, Blatt: "Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism." in: Journal of neurochemistry, Vol. 114, Issue 5, pp. 1414-23, 2010 (PubMed).