Interferon Related Developmental Regulator 1 (IFRD1) (Center) antibody

Antigen: Interferon Related Developmental Regulator 1 (IFRD1)

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654235

Additional Information

Alternative name: IFRD1

Gene ID: 3475

UniProt: O00458, NP_001007246.1, NP_001541.2

Immunogen: This IFRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-360 amino acids from the Central region of human IFRD1.

Isotype: Ig

Description: Other names: Interferon-related developmental regulator 1,IFRD1,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This IFRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-360 amino acids from the Central region of human IFRD1.

Molecular Weight: 50269 DA

Comments:

Background: This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure

Restrictions: For Research Use only

Images

IFRD1 antibody (Center) (ABIN654235) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IFRD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Gu, Harley, Henderson et al.: "Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease." in: Nature, Vol. 458, Issue 7241, pp. 1039-42, 2009 (PubMed).

Brkanac, Spencer, Shendure et al.: "IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23." in: American journal of human genetics, Vol. 84, Issue 5, pp. 692-7, 2009 (PubMed).

Zhao, Datta, Mandal et al.: "Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frame." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 8552-62, 2010 (PubMed).