Atlastin GTPase 2 (ATL2) (Center) antibody

Antigen: Atlastin GTPase 2 (ATL2)

Synonyms: arl6ip2, MGC83593, ATL2, ARL6IP2, fc06e01, wu:fc06e01, wu:fv60d03, Aip-2, Arl6ip2, AA407293, AV334690, 2010110I21Rik, ARL3IP2, FLJ23293, atlastin2

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654363

Additional Information

Alternative name: ATL2

Gene ID: 9719

UniProt: Q86TH1, NP_055509.2, NP_001138792.1

Immunogen: This ATL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-566 amino acids from the Central region of human ATL2.

Isotype: Ig

Description: Other names: ADAMTS-like protein 2,ADAMTSL2,KIAA0605

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ATL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-566 amino acids from the Central region of human ATL2.

Molecular Weight: 104621 DA

Comments:

Background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix, it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Le Goff, Morice-Picard, Dagoneau et al.: "ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation." in: Nature genetics, Vol. 40, Issue 9, pp. 1119-23, 2009 (PubMed).