E2F2 antibody (AA 258-286)

Catalog No. ABIN654438

Product Details anti-E2F2 Antibody

Target: E2F2 (E2F Transcription Factor 2 (E2F2))

Binding Specificity: AA 258-286

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This E2F2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This E2F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-286 amino acids from the Central region of human E2F2.

Clone: RB27633

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for E2F2

Target: E2F2 (E2F Transcription Factor 2 (E2F2))

Alternative Name: E2F2 (E2F2 Products)

Synonyms: E2F-2 antibody, CG1071 antibody, Dmel\\CG1071 antibody, E2F antibody, E2F2 antibody, dE2F-2 antibody, dE2F2 antibody, dE2f2 antibody, de2f2 antibody, e2f2 antibody, 9230110J10 antibody, E130207A07 antibody, fb40b03 antibody, wu:fb40b03 antibody, E2F transcription factor 2 antibody, si:ch211-160f23.5 antibody, E2F2 antibody, E2f2 antibody, si:ch211-160f23.5 antibody

Background: E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46 % amino acid identity to E2F1. [provided by RefSeq].

Molecular Weight: 47506

Gene ID: 1870

NCBI Accession: NP_004082

UniProt: Q14209

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication