UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 6 (B4GALT6) (C-Term), (AA 319-346) antibody

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Antigen
Epitope
C-Term, AA 319-346
(10), (8)
Reactivity
Human
(12), (3)
Host
Rabbit
(13)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(13), (8), (8), (7), (2), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN654654
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Immunogen This B4GALT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-346 AA from the C-terminal region of human B4GALT6.
Clone RB24270
Isotype Ig
Specificity This B4GALT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human B4GALT6.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name B4GALT6
Background This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose, all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis.
Synonyms: Beta-1,4-galactosyltransferase 6,B4GALT6,
Molecular Weight 44914 DA
Gene ID 9331
NCBI Accession NP_004766
UniProt Q9UBX8
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-UDP-Gal:betaGlcNAc beta 1,4 Galactosyltransferase, Polypeptide 6 (B4GALT6) (C-Term), (AA 319-346) antibody B4GALT6 Antibody (C-term) (ABIN654654) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Takizawa, Nomura, Wakisaka et al.: "cDNA cloning and expression of human lactosylceramide synthase." in: Biochimica et biophysica acta, Vol. 1438, Issue 2, pp. 301-4, 1999 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

Landers, Melki, Meininger et al.: "Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 22, pp. 9004-9, 2009 (PubMed).

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