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Details for Product No. ABIN654666

Within Bgcn Homolog (Drosophila) (WIBG) (N-Term), (AA 12-40) antibody

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Antigen
Synonyms A030010B05Rik, Pym, PYM, BEST:HL05757, CG10330, CG30176, Dmel\\CG30176, UD3
Epitope
»Alternatives N-Term, AA 12-40
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN654666
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 AA from the N-terminal region of human WIBG.
Clone RB28144
Isotype Ig
Specificity This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human WIBG.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WIBG
Background Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Synonyms: Partner of Y14 and mago,WIBG,PYM
Molecular Weight 22656 DA
Gene ID 84305
UniProt Q9BRP8, NP_115721.1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Gehring, Lamprinaki, Kulozik et al.: "Disassembly of exon junction complexes by PYM." in: Cell, Vol. 137, Issue 3, pp. 536-48, 2009 (PubMed).

Alternatives for antigen "Within Bgcn Homolog (Drosophila) (WIBG)", type "Antibodies"
Hosts (7)
Reactivities (6), (4)
Applications (7), (2), (2), (1)
Epitopes (3), (2), (2), (1), (1), (1)
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