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Within Bgcn Homolog (Drosophila) (WIBG) (N-Term), (AA 12-40) antibody

Details for Product No. ABIN654666
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Antigen
Synonyms A030010B05Rik, Pym, PYM, BEST:HL05757, CG10330, CG30176, Dmel\\CG30176, UD3
Epitope
N-Term, AA 12-40
(8), (8), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(12), (3)
Host
Rabbit
(13)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(13), (7), (7), (2)
Pubmed 1 reference available
Quantity 400 µL
Options
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Catalog No. ABIN654666
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 AA from the N-terminal region of human WIBG.
Clone RB28144
Isotype Ig
Specificity This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human WIBG.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WIBG
Background Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Synonyms: Partner of Y14 and mago,WIBG,PYM
Molecular Weight 22656 DA
Gene ID 84305
UniProt Q9BRP8, NP_115721.1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Within Bgcn Homolog (Drosophila) (WIBG) (N-Term), (AA 12-40) antibody WIBG antibody (N-term) (ABIN654666) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervical tissue followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Gehring, Lamprinaki, Kulozik et al.: "Disassembly of exon junction complexes by PYM." in: Cell, Vol. 137, Issue 3, pp. 536-48, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN654666
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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