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ORMDL3 antibody (ORM1-Like 3 (S. Cerevisiae)) (AA 53-81)

Details for Product anti-ORMDL3 Antibody No. ABIN654696, Supplier: Log in to see
  • 2810011N17Rik
  • AI315223
  • LRRGT00183
AA 53-81, Center
Human, Mouse (Murine)
Clonality (Clone)
Polyclonal ()
This ORMDL3 antibody is un-conjugated
Western Blotting (WB)
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Immunogen This ORMDL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-81 AA from the Central region of human ORMDL3.
Clone RB24096
Isotype Ig
Predicted Reactivity Cow (Bovine),Rat (Rattus),Xenopus laevis,Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ORMDL3 (ORMDL3 Antibody Abstract)
Background Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.

Synonyms: ORM1-like protein 3,ORMDL3,
Molecular Weight 17495 Da
Gene ID 94103
NCBI Accession NP_644809
UniProt Q8N138
Research Area Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ORMDL3 antibody (ORM1-Like 3 (S. Cerevisiae)) (AA 53-81) (ABIN654696) ORMDL3 Antibody (Center) (ABIN654696) western blot analysis in mouse testis tissue ly...
Product cited in: Carreras-Sureda, Cantero-Recasens, Rubio-Moscardo, Kiefer, Peinelt, Niemeyer, Valverde, Vicente: "ORMDL3 modulates store-operated calcium entry and lymphocyte activation." in: Human molecular genetics, Vol. 22, Issue 3, pp. 519-30, 2013 (PubMed).

Miller, Tam, Cho, Doherty, Pham, Khorram, Rosenthal, Mueller, Hoffman, Suzukawa, Niwa, Broide: "ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16648-53, 2012 (PubMed).

Background publications Fransen, Visschedijk, van Sommeren, Fu, Franke, Festen, Stokkers, van Bodegraven, Crusius, Hommes, Zanen, de Jong, Wijmenga, van Diemen, Weersma: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

Liu, Invernizzi, Lu, Kosoy, Lu, Bianchi, Podda, Xu, Xie, Macciardi, Selmi, Lupoli, Shigeta, Ransom, Lleo, Lee, Mason, Myers, Peltekian, Ghent, Bernuzzi, Zuin, Rosina, Borghesio, Floreani et al.: "Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis...." in: Nature genetics, Vol. 42, Issue 8, pp. 658-60, 2010 (PubMed).

Halapi, Gudbjartsson, Jonsdottir, Bjornsdottir, Thorleifsson, Helgadottir, Williams, Koppelman, Heinzmann, Boezen, Jonasdottir, Blondal, Gudjonsson, Jonasdottir, Thorlacius, Henry, Altmueller, Krueger, Shin, Uh, Cheong, Jonsdottir, Ludviksson, Ludviksdott: "A sequence variant on 17q21 is associated with age at onset and severity of asthma." in: European journal of human genetics : EJHG, Vol. 18, Issue 8, pp. 902-8, 2010 (PubMed).

McGovern, Gardet, Törkvist, Goyette, Essers, Taylor, Neale, Ong, Lagacé, Li, Green, Stevens, Beauchamp, Fleshner, Carlson, DAmato, Halfvarson, Hibberd, Lördal, Padyukov, Andriulli, Colombo, Latiano et al.: "Genome-wide association identifies multiple ulcerative colitis susceptibility loci. ..." in: Nature genetics, Vol. 42, Issue 4, pp. 332-7, 2010 (PubMed).