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Lysyl-tRNA Synthetase (KARS) (AA 70-98), (N-Term) antibody

Details for Product No. ABIN655049, Supplier: Log in to see
Antigen
  • CG12141
  • Dmel\\CG12141
  • KRS
  • LysRS
  • cb530
  • wu:fa16h02
  • zgc:92483
  • kars
  • MGC53345
  • kars2
  • krs
  • krs-1
  • KARS
  • Tb06.28P18.190
  • CMTRIB
  • DFNB89
  • KARS1
  • KARS2
  • AA589550
  • AL024334
  • AL033315
  • AL033367
  • D8Ertd698e
  • D8Wsu108e
  • mKIAA0070
Epitope
AA 70-98, N-Term
6
5
5
4
1
1
Reactivity
Human
48
23
19
1
Host
Rabbit
38
11
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
35
18
18
12
11
4
4
4
3
1
1
Supplier
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Immunogen This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 AA from the N-terminal region of human KARS.
Clone RB14918
Isotype Ig
Specificity This KARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the N-terminal region of human KARS.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name KARS (KARS Antibody Abstract)
Background Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Lysyl-tRNA synthetase,KARS,KIAA0070
Molecular Weight 68048 DA
Gene ID 3735
NCBI Accession NP_005539, NP_001123561
UniProt Q15046
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin
Pathways
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Lysyl-tRNA Synthetase (KARS) (AA 70-98), (N-Term) antibody (ABIN655049) KARS Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane)....
Western Blotting (WB) image for anti-Lysyl-tRNA Synthetase (KARS) (AA 70-98), (N-Term) antibody (ABIN655049) Western blot analysis of KARS (arrow) using rabbit polyclonal KARS Antibody (N-term) ...
Flow Cytometry (FACS) image for anti-Lysyl-tRNA Synthetase (KARS) (AA 70-98), (N-Term) antibody (ABIN655049) KARS Antibody (N-term) flow cytometric analysis of 293 cells (right histogram) compa...
Background publications McLaughlin, Sakaguchi, Liu et al.: "Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy." in: American journal of human genetics, Vol. 87, Issue 4, pp. 560-6, 2010 (PubMed).

Kawamata, Magrané, Kunst et al.: "Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria." in: The Journal of biological chemistry, Vol. 283, Issue 42, pp. 28321-8, 2008 (PubMed).