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Details for Product No. ABIN655165

F-Box Protein, Helicase, 18 (FBXO18) (C-Term), (AA 741-769) antibody

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Synonyms AU015756, Fbh1, Fbx18, FBH1
»Alternatives C-Term, AA 741-769
»Alternatives Mouse (Murine)
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN655165
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This FBXO18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 741-769 AA from the C-terminal region of human FBXO18.
Clone RB18055
Isotype Ig
Specificity This FBXO18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 748-777 amino acids from the C-terminal region of human FBXO18.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FBXO18
Background This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms: FBXO18,F-box only protein 18,FBH1, FBX18
Molecular Weight 117686 DA
Gene ID 84893
UniProt NP_835363, Q8NFZ0
Research Area Cell Structure, Signaling, Chromatin, Metabolism, Transcription Factors
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Chiolo, Saponaro, Baryshnikova et al.: "The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles." in: Molecular and cellular biology, Vol. 27, Issue 21, pp. 7439-50, 2007 (PubMed).

Fugger, Mistrik, Danielsen et al.: "Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 655-63, 2009 (PubMed).

Turnbull, Ahmed, Morrison et al.: "Genome-wide association study identifies five new breast cancer susceptibility loci." in: Nature genetics, Vol. 42, Issue 6, pp. 504-7, 2010 (PubMed).

Alternatives for antigen "F-Box Protein, Helicase, 18 (FBXO18)", type "Antibodies"
Hosts (17), (4)
Reactivities (20), (17), (14), (12)
Applications (10), (9), (6), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (1)