FBXO18 antibody (F-Box Protein, Helicase, 18) (AA 741-769)

Details for Product anti-FBXO18 Antibody No. ABIN655165, Supplier: Log in to see
Antigen
  • AU015756
  • Fbh1
  • Fbx18
  • FBH1
  • F-box protein, helicase, 18
  • F-box protein 18
  • Fbxo18
  • FBXO18
Epitope
AA 741-769, C-Term
10
9
8
1
Reactivity
Mouse (Murine)
23
19
5
Host
Rabbit
28
6
Clonality (Clone)
Polyclonal ()
Conjugate
This FBXO18 antibody is un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
27
20
4
3
3
2
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen This FBXO18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 741-769 AA from the C-terminal region of human FBXO18.
Clone RB18055
Isotype Ig
Specificity This FBXO18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 748-777 amino acids from the C-terminal region of human FBXO18.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FBXO18 (FBXO18 Antibody Abstract)
Background This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms: FBXO18,F-box only protein 18,FBH1, FBX18
Molecular Weight 117686 DA
Gene ID 84893
NCBI Accession NP_835363
UniProt Q8NFZ0
Research Area Cell Structure, Signaling, Chromatin, Metabolism, Transcription Factors
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FBXO18 antibody (F-Box Protein, Helicase, 18) (AA 741-769) (ABIN655165) FBXO18 Antibody (C-term) (ABIN655165) western blot analysis in mouse heart tissue lys...
Background publications Turnbull, Ahmed, Morrison, Pernet, Renwick, Maranian, Seal, Ghoussaini, Hines, Healey, Hughes, Warren-Perry, Tapper, Eccles, Evans, , Hooning, Schutte, van den Ouweland, Houlston, Ross, Langford, Pharoah, Stratton, Dunning, Rahman, Easton: "Genome-wide association study identifies five new breast cancer susceptibility loci." in: Nature genetics, Vol. 42, Issue 6, pp. 504-7, 2010 (PubMed).

Fugger, Mistrik, Danielsen, Dinant, Falck, Bartek, Lukas, Mailand: "Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 655-63, 2009 (PubMed).

Chiolo, Saponaro, Baryshnikova, Kim, Seo, Liberi: "The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles." in: Molecular and cellular biology, Vol. 27, Issue 21, pp. 7439-50, 2007 (PubMed).

Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ..." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).