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Autophagy Related 4D, Cysteine Peptidase (ATG4D) (N-Term), (AA 42-71) antibody

Details for Product No. ABIN655395
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Antigen
Epitope
N-Term, AA 42-71
(12), (12), (12), (7), (5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(84), (60), (40), (38), (38), (36)
Host
Rabbit
(82), (10), (3), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC)
(56), (40), (26), (19), (15), (6), (5), (3)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN655395
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Immunogen This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 AA from the N-terminal region of human ATG4D.
Clone RB14788
Isotype Ig
Specificity This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human ATG4D.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ATG4D
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Synonyms: ATG4D,Cysteine protease ATG4D,APG4D, AUTL4
Molecular Weight 52922 DA
Gene ID 84971
UniProt NP_116274.3, Q86TL0
Research Area Autophagy, Cell Structure, Metabolism
Application Notes IF = 1:200, WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) (N-Term), (AA 42-71) antibody ATG4D Antibody (N-term) (ABIN655395) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Betin, Lane: "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2554-66, 2009 (PubMed).

Validation Images
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