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SP1 antibody (Sp1 Transcription Factor) (AA 677-707)

Details for Product anti-SP1 Antibody No. ABIN655398, Supplier: Log in to see
Antigen
  • 1110003E12Rik
  • AA450830
  • AI845540
  • fc18h09
  • SP1
  • Sp1-1
  • wu:fc18h09
  • zgc:85950
Epitope
AA 677-707, C-Term
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11
8
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1
1
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1
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1
Reactivity
Human
228
96
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11
7
5
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2
2
1
1
1
Host
Rabbit
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35
17
Clonality (Clone)
Polyclonal ()
Conjugate
This SP1 antibody is un-conjugated
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7
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4
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4
2
2
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Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
199
100
70
64
35
35
23
22
18
5
4
3
3
1
1
Supplier
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Immunogen This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 AA from the C-terminal region of human SP1.
Clone RB17350
Isotype Ig
Specificity This SP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 684-715 amino acids from the C-terminal region of human SP1.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SP1 (SP1 Antibody Abstract)
Background Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Synonyms: SP1,Transcription factor Sp1,TSFP1
Molecular Weight 80693 DA
Gene ID 6667
NCBI Accession NP_612482, NP_003100
UniProt P08047
Research Area Cell Structure, Signaling, Protein Modifications, Phospho-specific antibodies, Transcription Factors, Translation Factors, Ubiquitin-related antibodies
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-SP1 antibody (Sp1 Transcription Factor) (AA 677-707) (ABIN655398) SP1 Antibody (C-term P692) (ABIN655398) flow cytometric analysis of K562 cells (right...
Background publications Pan, Yang, Wei, Sun, Li: "SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation." in: Biochemical and biophysical research communications, Vol. 401, Issue 2, pp. 306-12, 2010 (PubMed).

Mucha, Ooi, Linley, Mordaka, Dalle, Robertson, Gamper, Wood: "Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 40, pp. 13235-45, 2010 (PubMed).

Imanishi, Imamura, Higashi, Yan, Negi, Futaki, Sugiura: "Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp1." in: Biochemical and biophysical research communications, Vol. 400, Issue 4, pp. 625-30, 2010 (PubMed).

Jutooru, Chadalapaka, Lei, Safe: "Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25332-44, 2010 (PubMed).