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DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11) (AA 819-847), (C-Term) antibody

Details for Product No. ABIN655503, Supplier: Log in to see
Antigen
  • CHL1
  • CHLR1
  • KRG2
  • WABS
  • 4732462I11Rik
  • essa15a
Epitope
AA 819-847, C-Term
17
16
16
9
7
5
3
2
1
1
1
1
Reactivity
Human
66
6
2
Host
Rabbit
57
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
50
35
31
11
7
5
5
2
1
Supplier
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Immunogen This DDX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 819-847 AA from the C-terminal region of human DDX11.
Clone RB17677
Isotype Ig
Specificity This DDX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 826-855 amino acids from the C-terminal region of human DDX11.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DDX11 (DDX11 Antibody Abstract)
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms: Probable ATP-dependent RNA helicase DDX11,DDX11,CHL1, CHLR1, KRG2
Molecular Weight 108313 DA
Gene ID 1663
NCBI Accession NP_004390, NP_689651
UniProt Q96FC9
Research Area Cell Structure, Signaling, Chromatin, Metabolism, Transcription Factors
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.29 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11) (AA 819-847), (C-Term) antibody (ABIN655503) DDX11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane)....
Flow Cytometry (FACS) image for anti-DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11) (AA 819-847), (C-Term) antibody (ABIN655503) DDX11 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) com...
Background publications Leman, Noguchi, Lee et al.: "Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 660-70, 2010 (PubMed).

Farina, Shin, Kim et al.: "Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1." in: The Journal of biological chemistry, Vol. 283, Issue 30, pp. 20925-36, 2008 (PubMed).

Parish, Bean, Park et al.: "ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance." in: Molecular cell, Vol. 24, Issue 6, pp. 867-76, 2006 (PubMed).

Parish, Rosa, Wang et al.: "The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 23, pp. 4857-65, 2006 (PubMed).