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Killin, p53-Regulated DNA Replication Inhibitor (KLLN) (AA 136-163), (C-Term) antibody

Details for Product No. ABIN655558, Supplier: Log in to see
Antigen
  • CWS4
  • KILLIN
Epitope
AA 136-163, C-Term
19
17
1
1
1
Reactivity
Human
27
2
2
Host
Rabbit
27
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Western Blotting (WB)
24
16
2
1
1
Supplier
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Immunogen This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 AA from the C-terminal region of human KILLIN.
Clone RB29503
Isotype Ig
Specificity This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the C-terminal region of human KILLIN.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KILLIN (KLLN Antibody Abstract)
Background DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating TP53/p53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double-and single-stranded DNA.
Synonyms: Killin
Molecular Weight 19958 DA
Gene ID 100144748
NCBI Accession NP_001119521
UniProt B2CW77
Research Area Apoptosis/Necrosis, Cell Structure, Signaling, Transcription Factors
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Killin, p53-Regulated DNA Replication Inhibitor (KLLN) (AA 136-163), (C-Term) antibody (ABIN655558) KILLIN Antibody (C-term) (ABIN655558) western blot analysis in MDA-MB435 cell line ly...
Product cited in: Wang, Roma, Nolley et al.: "Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma." in: Endocrine-related cancer, Vol. 21, Issue 4, pp. 579-86, 2014 (PubMed).

Wang, Yu, He et al.: "Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation." in: Molecular cancer therapeutics, Vol. 13, Issue 2, pp. 517-27, 2014 (PubMed).

Wang, He, Yu et al.: "Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2263-72, 2013 (PubMed).

Background publications Cho, Liang: "Killin is a p53-regulated nuclear inhibitor of DNA synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 14, pp. 5396-401, 2008 (PubMed).