Fibroblast Growth Factor 17 (FGF17) (C-Term) antibody

Antigen: Fibroblast Growth Factor 17 (FGF17)

Synonyms: FGF-13, fgf17b, MGC101759, zgc:101759, FGF17

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655584

Additional Information

Alternative name: FGF17

Gene ID: 8822

UniProt: NP_003858.1, O60258

Immunogen: This FGF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-213 amino acids from the C-terminal region of human FGF17.

Isotype: Ig

Description: Other names: Fibroblast growth factor 17,FGF17,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This FGF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-213 amino acids from the C-terminal region of human FGF17.

Molecular Weight: 24891 DA

Comments:

Background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure, Protein Modifications, Cell Cycle, Cell Signaling

Restrictions: For Research Use only

Images

FGF17 Antibody (C-term) (ABIN655584) western blot analysis in NCI-H460,Jurkat cell line lysates (35ug/lane). This demonstrates the FGF17 antibody detected the FGF17 protein (arrow).

Publications

Product: Popovici, Conchonaud, Birnbaum et al.: "Functional phylogeny relates LET-756 to fibroblast growth factor 9." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 40146-52, 2004 (PubMed).

Olsen, Li, Bromleigh et al.: "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain." in: Genes & development, Vol. 20, Issue 2, pp. 185-98, 2006 (PubMed).

Zhang, Ibrahimi, Olsen et al.: "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." in: The Journal of biological chemistry, Vol. 281, Issue 23, pp. 15694-700, 2006 (PubMed).

Moffa, Ethier: "Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells." in: Journal of cellular physiology, Vol. 210, Issue 3, pp. 720-31, 2007 (PubMed).

Wen, Liu, Xu et al.: "Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis." in: Nature genetics, Vol. 41, Issue 2, pp. 228-33, 2009 (PubMed).