|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Fibroblast Growth Factor 17 (FGF17) (C-Term) antibody
|Synonyms||FGF-13, fgf17b, MGC101759, zgc:101759, FGF17|
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This FGF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-213 amino acids from the C-terminal region of human FGF17.|
|Description||Other names: Fibroblast growth factor 17,FGF17,|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This FGF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-213 amino acids from the C-terminal region of human FGF17.|
|Molecular Weight||24891 DA|
Background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure, Protein Modifications, Cell Cycle, Cell Signaling|
|Restrictions||For Research Use only|
|FGF17 Antibody (C-term) (ABIN655584) western blot analysis in NCI-H460,Jurkat cell line lysates (35ug/lane). This demonstrates the FGF17 antibody detected the FGF17 protein (arrow).|
Popovici, Conchonaud, Birnbaum et al.: "Functional phylogeny relates LET-756 to fibroblast growth factor 9." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 40146-52, 2004 (PubMed).
Olsen, Li, Bromleigh et al.: "Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain." in: Genes & development, Vol. 20, Issue 2, pp. 185-98, 2006 (PubMed).
Zhang, Ibrahimi, Olsen et al.: "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." in: The Journal of biological chemistry, Vol. 281, Issue 23, pp. 15694-700, 2006 (PubMed).
Moffa, Ethier: "Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells." in: Journal of cellular physiology, Vol. 210, Issue 3, pp. 720-31, 2007 (PubMed).
Wen, Liu, Xu et al.: "Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis." in: Nature genetics, Vol. 41, Issue 2, pp. 228-33, 2009 (PubMed).
|Hosts||Rabbit (31), Goat (9), Mouse (4)|
|Reactivities||Human (42), Mouse (Murine) (18)|
|Applications||ELISA (27), Western Blotting (WB) (24), Immunofluorescence (IF) (15), Functional Studies (Func) (5), Neutralization (Neut) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Blocking Antibody (Inhibition) (2), Blocking Antibody (Inhibition) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Biotin (8), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (1), Internal Region (1)|