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Mesoderm Development Candidate 2 (MESDC2) (AA 206-234), (C-Term) antibody

Details for Product No. ABIN655585, Supplier: Login to see
Antigen
  • MGC115616
  • MESDC2
  • BOCA
  • MESD
  • 2210015O11Rik
  • AW537813
  • mKIAA0081
  • mesd
  • msd
  • zgc:158636
Epitope
AA 206-234, C-Term
17
16
3
2
1
1
1
Reactivity
Human
31
4
3
2
Host
Rabbit
28
5
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
30
20
18
10
6
4
2
2
1
Supplier
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Immunogen This MESDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 AA from the C-terminal region of human MESDC2.
Clone RB29835
Isotype Ig
Specificity This MESDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-234 amino acids from the C-terminal region of human MESDC2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MESDC2 (MESDC2 Antibody Abstract)
Background Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
Synonyms: LDLR chaperone MESD,MESDC2,KIAA0081, MESD
Molecular Weight 26077 Da
Gene ID 23184
UniProt Q14696
Research Area Cell Structure, Protein Modifications, Cell Signaling
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Mesoderm Development Candidate 2 (MESDC2) (AA 206-234), (C-Term) antibody (ABIN655585) MESDC2 Antibody (C-term) (ABIN655585) western blot analysis in Hela,293,HepG2 cell li...
Background publications Murrills, Matteo, Bhat et al.: "A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V)." in: Journal of cellular biochemistry, Vol. 108, Issue 5, pp. 1066-75, 2009 (PubMed).

Li, Lu, He et al.: "Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd." in: FEBS letters, Vol. 580, Issue 22, pp. 5423-8, 2006 (PubMed).

Veltman, Vreede, Cheng et al.: "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional ..." in: Human molecular genetics, Vol. 14, Issue 14, pp. 1955-63, 2005 (PubMed).