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Mesoderm Development Candidate 2 (MESDC2) (C-Term), (AA 206-234) antibody

Details for Product No. ABIN655585
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Antigen
Synonyms BOCA, MESD, 2210015O11Rik, AW537813, mKIAA0081, mesd, msd, MGC115616, zgc:158636, MESDC2
Epitope
C-Term, AA 206-234
(8), (8), (1), (1)
Reactivity
Human
(14), (3), (3), (2)
Host
Rabbit
(13), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
(16), (9), (9), (7), (3), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN655585
238.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This MESDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 AA from the C-terminal region of human MESDC2.
Clone RB29835
Isotype Ig
Specificity This MESDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-234 amino acids from the C-terminal region of human MESDC2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MESDC2
Background Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.
Synonyms: LDLR chaperone MESD,MESDC2,KIAA0081, MESD
Molecular Weight 26077 Da
Gene ID 23184
UniProt Q14696
Research Area Cell Structure, Protein Modifications, Cell Signaling
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Mesoderm Development Candidate 2 (MESDC2) (C-Term), (AA 206-234) antibody MESDC2 Antibody (C-term) (ABIN655585) western blot analysis in Hela,293,HepG2 cell line lysates (35 µg/lane). This demonstrates the MESDC2 antibody detected the MESDC2 protein (arrow).
Background publications Veltman, Vreede, Cheng et al.: "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)." in: Human molecular genetics, Vol. 14, Issue 14, pp. 1955-63, 2005 (PubMed).

Li, Lu, He et al.: "Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd." in: FEBS letters, Vol. 580, Issue 22, pp. 5423-8, 2006 (PubMed).

Murrills, Matteo, Bhat et al.: "A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V)." in: Journal of cellular biochemistry, Vol. 108, Issue 5, pp. 1066-75, 2009 (PubMed).

Hosts (13), (3)
Reactivities (14), (3), (3), (2)
Applications (16), (9), (9), (7), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1)
Epitopes (8), (8), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN655585
238.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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