Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5) (C-Term) antibody

Antigen: Ras Association (RalGDS/AF-6) Domain Family Member 5 (RASSF5)

Synonyms: Rapl, Maxp1, Nore1, Nore1A, Nore1B, AU042887, MGC107647, 1300019G20Rik, RAPL, NORE1, NORE1A, NORE1B, RASSF3, MGC10823, MGC17344

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655644

Additional Information

Alternative name: NORE1

Gene ID: 83593

UniProt: NP_872605.1, NP_872604.1, Q8WWW0, NP_872606.1

Immunogen: This NORE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the C-terminal region of human NORE1.

Isotype: Ig

Description: Other names: RB20025

Characteristics: Synthetic peptide

Specificity: This NORE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-335 amino acids from the C-terminal region of human NORE1.

Molecular Weight: 47090 DA

Comments:

Background: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Apoptosis/Necrosis, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure

Restrictions: For Research Use only

Images

NORE1 Antibody (C-term) (ABIN655644) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NORE1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Raab, Wang, Lu et al.: "T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes." in: Immunity, Vol. 32, Issue 4, pp. 541-56, 2010 (PubMed).