COL8a2 antibody (C-Term)

Catalog No. ABIN655804

Product Details anti-COL8a2 Antibody

Target: COL8a2 (COL8A2) (Collagen, Type VIII, alpha 2 (COL8A2))

Binding Specificity: AA 571-599, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL8a2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COL8A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-599 amino acids from the C-terminal region of human COL8A2.

Clone: RB31742

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:2000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-COL8a2 antibody (ABIN655804)

Okumura, Minamiyama, Ho, Kay, Kawasaki, Tourtas, Schlötzer-Schrehardt, Kruse, Young, Quantock, Kinoshita, Koizumi: "Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 95, Issue 11, pp. 1291-304, (2015) (PubMed).

Target Details for COL8a2

Target: COL8a2 (COL8A2) (Collagen, Type VIII, alpha 2 (COL8A2))

Alternative Name: COL8A2 (COL8A2 Products)

Synonyms: FECD antibody, FECD1 antibody, PPCD antibody, PPCD2 antibody, AI429819 antibody, collagen type VIII alpha 2 chain antibody, collagen, type VIII, alpha 2 antibody, COL8A2 antibody, Col8a2 antibody

Background: This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2.

Molecular Weight: 67244

Gene ID: 1296

NCBI Accession: NP_005193

UniProt: P25067