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TNFSF15 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 15) (AA 148-175)

Details for Product anti-TNFSF15 Antibody No. ABIN655822, Supplier: Log in to see
Antigen
  • TTPAL
  • TL1
  • TL1A
  • VEGI
  • VEGI192A
  • Tl1
  • Tl1a
  • Vegi
  • tumor necrosis factor (ligand) superfamily, member 15
  • TNFSF15
  • Tnfsf15
Epitope
AA 148-175, Center
14
12
11
10
9
9
7
4
4
3
3
3
3
3
1
1
1
1
1
Reactivity
Human
175
45
30
Host
Rabbit
125
56
Clonality (Clone)
Polyclonal ()
Conjugate
This TNFSF15 antibody is un-conjugated
9
6
6
5
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
156
77
49
46
31
27
15
13
8
8
3
2
2
2
1
Options
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Immunogen This TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-175 AA from the Central region of human TNFSF15.
Clone RB21818
Isotype Ig
Specificity This TNFSF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human TNFSF15.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TNFSF15 (TNFSF15 Antibody Abstract)
Background The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq].
Synonyms: Tumor necrosis factor ligand superfamily member 15,TNFSF15,TL1, VEGI
Molecular Weight 28087 DA
Gene ID 9966
NCBI Accession NP_005109
UniProt O95150
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
 image for anti-TNFSF15 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 15) (AA 148-175) (ABIN655822) Confocal immunofluorescent analysis of TNFSF15 Antibody (Center) (ABIN655822) with He...
Background publications Amre, Mack, Morgan, Israel, Deslandres, Seidman, Lambrette, Costea, Krupoves, Fegury, Dong, Xhu, Grimard, Levy: "Association between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children." in: Human genetics, Vol. 128, Issue 2, pp. 131-5, 2010 (PubMed).

Heidemann, Chavez, Landers, Kucharzik, Prehn, Targan: "TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets." in: Journal of clinical immunology, Vol. 30, Issue 4, pp. 531-8, 2010 (PubMed).

McLaren, Calder, McSharry, Sexton, Salter, Singh, Wilkinson, Wang, Ramji: "The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 10, pp. 5827-34, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Nakagome, Takeyama, Mano, Sakisaka, Matsui, Kawamura, Oota: "Population-specific susceptibility to Crohn's disease and ulcerative colitis; dominant and recessive relative risks in the Japanese population." in: Annals of human genetics, Vol. 74, Issue 2, pp. 126-36, 2010 (PubMed).