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RAP1GDS1 antibody (RAP1, GTP-GDP Dissociation Stimulator 1) (AA 217-244)

Details for Product anti-RAP1GDS1 Antibody No. ABIN655886, Supplier: Log in to see
Antigen
  • BC011279
  • gds1
  • GDS1
  • rap1gds1
  • smgGDS
  • SmgGDS
  • XsmgGDS
Epitope
AA 217-244, Center
16
14
10
3
2
2
1
1
1
Reactivity
Human
50
19
4
Host
Rabbit
48
2
Clonality (Clone)
Polyclonal ()
Conjugate
This RAP1GDS1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
36
21
17
11
9
3
1
1
1
Supplier
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Immunogen This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 AA from the Central region of human RAP1GDS1.
Clone RB31690
Isotype Ig
Specificity This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the Central region of human RAP1GDS1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RAP1GDS1 (RAP1GDS1 Antibody Abstract)
Background The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).
Synonyms: Rap1 GTPase-GDP dissociation stimulator 1,RAP1GDS1,
Molecular Weight 66317 DA
Gene ID 5910
NCBI Accession NP_001093900
UniProt P52306
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes IHC (p) = 1:10-50, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-RAP1GDS1 antibody (RAP1, GTP-GDP Dissociation Stimulator 1) (AA 217-244) (ABIN655886) RAP1GDS1 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraff...
Western Blotting (WB) image for anti-RAP1GDS1 antibody (RAP1, GTP-GDP Dissociation Stimulator 1) (AA 217-244) (ABIN655886) RAP1GDS1 Antibody (Center) western blot analysis in HepG2,MDA-MB231 cell line lysate...
Background publications Schönherr, Yang, Vigny, Palmer, Hallberg: "Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells." in: Oncogene, Vol. 29, Issue 19, pp. 2817-30, 2010 (PubMed).

Branham, Bustos, De Blas, Rehmann, Zarelli, Treviño, Darszon, Mayorga, Tomes: "Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24825-39, 2009 (PubMed).

Tiwari, Felekkis, Moon, Flies, Sherr, Lerner: "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis." in: Blood, Vol. 103, Issue 7, pp. 2661-7, 2004 (PubMed).